PEGG: Recent Research

Toxicity of the Unresolved Complex Mixture (UCM) of a Petrogenic Oil
Knut-Erik Tollefsen¹, Jorunn N. Hokstad², Alf G. Melbye², Odd G. Brakstad², Andy Booth², Steve Rowland³, Inger K. Gregersen¹ and Bjørn Henrik Hansen²
¹	NIVA, Oslo, Norway
²	SINTEF – Materials and Chemistry, Marine Environmental Technology, 7465 Trondheim, Norway
³	University of Plymouth, Plymouth, U.K.
Presented at: 5^th SETAC World Congress, Sydney, Australia, 3-7 August 2008.
Download: Poster as an A4 pdf file.

Brief Summary

What are unresolved complex mixtures?

Poorly characterized oil compounds
Often referred to as "chromatographic humps"
Comprise thousands of unidentified compounds
In some oils UCMs may comprise over 50% of the organic material in the water soluble fractions (WSF)
UCMs have shown to be toxic and persistent

Objectives of the study

Fractionate WSF of a Norwegian Sea oil based on polarity by HPLC
Determine toxicity in individual fractions by in vitro bioassays
Generate synthetic mixtures of target analytes (from Norwegian regulatory monitoring) in selected fractions and test them for toxicity
Evaluate the toxicity of the unknown oil compounds by comparing toxicity data of HPLC-fractions with those of synthetic mixtures

Download the complete poster as an A4 pdf file.

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